Topic 250 WORDS: Glycolysis, Warburg effect & Cancer: Role of thiols?
This week you learned about glycolysis and the chemical reactions and enzymes involved in this important metabolic pathway. You further learned that glyceraldehyde phosphate dehydrogenase (GAPDH) enzyme is not only an important key regulatory enzyme of glycolysis, but also recognized as a “moonshining” enzyme. GAPDH is also long known as an enzyme that is prone to inhibition by many toxins, e.g., Pertussis toxin, alkylating agents and many thiol compounds. You also heard about the Warburg effect in connection with glycolysis.
As you work on this week’s discussion board assignment, consider the following:
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